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10.1038/tp.2017.171 13 FlintJ.KendlerK

NRF2 is subsequently stabilized to transcriptionally upregulate antioxidant response genes including xCT, the rate-limiting enzyme in glutathione synthesis, glutamate cysteine ligase (GCL), and enzymes used in detoxification of ROS, such as GPx [42], to attenuate ROS damage

Patients recovering from COVID-19 have reported cognitive problems such as decreased memory and attention and sleep disorder